In silico refers to the use of computer simulations to study something, as opposed to studying it in the real world. This can be used to study anything from the behavior of subatomic particles to the spread of disease. In silico experiments are often used to complement or replace real-world experiments, as they can be cheaper and easier to control.
Some of the emerging trends in In Silico include the use of machine learning for predictive modeling, the use of big data for data-driven discovery, and the use of cloud computing for high-performance computing.